Blar i NTNU Open på forfatter "Jensen, Vidar"
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Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice
Åbjørsbråten, Knut Sindre; Skaaraas, Gry HE Syverstad; Cunen, Celine Marie Løken; Bjørnstad, Daniel Marelius; Binder, Kristin M Gullestad; Bojarskaite, Laura; Jensen, Vidar; Nilsson, Lars; Rao, Shreyas B.; Tang, Wannan; Hermansen, Gudmund Horn; Nagelhus, Erlend Arnulf; Ottersen, Ole Petter; Torp, Reidun; Enger, Rune (Peer reviewed; Journal article, 2022)Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in such mice. Here, we employ an event-based ... -
Increased membrane Ca<sup>2+</sup> permeability drives astrocytic Ca<sup>2+</sup> dynamics during neuronal stimulation at excitatory synapses
Hjukse, Jarand Berg; Fernández de la Puebla, Mario; Vindedal, Gry Fluge; Sprengel, Rolf; Jensen, Vidar; Nagelhus, Erlend Arnulf; Tang, Wannan (Peer reviewed; Journal article, 2023)Astrocytes are intricately involved in the activity of neural circuits; however, their basic physiology of interacting with nearby neurons is not well established. Using two-photon imaging of neurons and astrocytes during ... -
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar; Bugaj, Anna Maria; Fernandez Berrocal, Marion Silvana; SIkko, Sunniva Bøe; Vetlesen, Susanne; Kusnierczyk, Anna; Olsen, Ann-Karin Hardie; Gutzkow, Kristine Bjerve; Rowe, Alexander D.; Wang, Wei; Moldestad, Olve; Syrstad, Monika; Slupphaug, Geir; Eide, Lars; Klungland, Arne; Sætrom, Pål; Luna, Luisa; Ye, Jing; Scheffler, Katja; Bjørås, Magnar (Peer reviewed; Journal article, 2021)Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 ... -
Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
Bertocchi, Ilaria; Eltokhi, Ahmed; Rozov, Andrey; Nguyễn Chi, Vivan; Jensen, Vidar; Bus, Thorsten; Pawlak, Verena; Serafino, Marta; Sonntag, Hannah; Yang, Boyi; Burnashev, Nail; Li, Shi-Bin; Obenhaus, Horst-Andreas; Both, Martin; Niewoehner, Burkhard; Single, Frank N.; Briese, Michael; Boerner, Thomas; Gass, Peter; Rawlins, John Nick P.; Köhr, Georg; Bannerman, David M.; Sprengel, Rolf (Peer reviewed; Journal article, 2021)The NMDA receptor-mediated Ca2+ signaling during simultaneous pre- and postsynaptic activity is critically involved in synaptic plasticity and thus has a key role in the nervous system. In GRIN2-variant patients alterations ...